Team members

Physical approaches to cell dynamics and tissue morphogenesis

We aim to understand the physical principles that underpin the morphogenesis of animals. To do so, we develop and apply quantitative approaches to observe, perturb and predict morphogenetic movements.

Our work addresses fundamental questions in the morphogenesis of multicellular systems: how do cells generate, transmit and respond to mechanical forces, from the supramolecular to the multicellular scale? How are these forces coupled to cell signaling and differentiation processes?  How do organized and functional structures emerge from such interactions? To  address  these questions, we focus on three aspects of morphogenesis:

(1) The organization and supramolecular dynamics of cell contacts;

(2) The mechanics of cell contacts and their remodeling;

(3) The mechanochemical state changes in multicellular self-organization.

We develop both experimental and theoretical approaches to study several in vivo and in vitro multicellular systems : the Drosophila and C. elegans embryos, and mouse embryonic organoids. The originality of our approach lies in the integration of both physics (imaging/mechanics/modeling) and experimental biology to study tissue morphogenesis quantitatively.

Fluorescence microscopy of a C. elegans embryo: membranes in cyan and histone in orange

Publications

Our last publications

News

of the team

Alumni

They contributed to our research
Hashmi Ali
University of Helsinki, postdoctoral fellow
Rulquin Charlotte
Marseille, high school professor
Kong Weiyuan
University of Paris, postdoctoral fellow
Monika Ludanyi
Veracyte, Inc., Product Development Team Leader
Girish Kale, Heidelberg
Postdoctoral fellow
Anaïs Baille, Dresden
Postdoctoral fellow
Eunice Chan
Aix Marseille University, engineer
Olivier Loison
BearingPoint, Paris, data scientist
Pierre Mangeol
Aix Marseille University, lecturer
Rémy Flores Flores
Toulouse, I2MC, Imaging facility leader
Olga Markova
Polytechnique LadHyX, postdoctoral fellow
Binh An Truongquang
Totalenergies Paris, lead data scientist
Jérémie Capoulade
System Engineer, European Space Agency, Netherlands
Matteo Rauzi
University of Nice, France, group leader

Funding bodies

They support our research

Gallery