Teams
INSTITUT DE BIOLOGIE DU DEVELOPPEMENT DE MARSEILLE

Actualités

Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids

The Lenne team published in Elife: using gastruloids –3D aggregates of mouse embryonic stem cells- they study at cellular resolution the specification of the endoderm.
Delphine Dauga
Delphine Dauga
Biocurator at Bioself
Date de publication

Shaping the body plan is a complex process that involves the spatial organization and patterning of the different germ layers. Using gastruloids –3D aggregates of mouse embryonic stem cells- we study at cellular resolution the specification of the endoderm. First, we show that contrary to mesoderm, nascent endoderm does not undergo epithelial-mesenchymal transition. Second, we provide evidence for a role of tissue flow, and heterogeneity of cellular junction tension, in the sorting and differentiation of the islets of endoderm cells.

To know more

Hashmi A, Tlili S, Perrin P, Lowndes M, Peradziryi H, Brickman JM, Martínez Arias A, Lenne PF. Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids. Elife. 2022 Apr 11;11:e59371. doi: 10.7554/eLife.59371. PMID: 35404233; PMCID: PMC9033300.

Contact

Pierre-François Lenne

Catégories

Dernières publications

AGENDA

OFFRES D'EMPLOI

Pattern formation by self-organized cell movement

The selected candidate will receive training in the following areas: molecular biology, cell biology, Xenopus micro-injection and micro-surgery, fluorescent confocal microscopy, video-microscopy, numerical image analysis.

TWITTER