INSTITUT DE BIOLOGIE DU DEVELOPPEMENT DE MARSEILLE

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Epigenetic factors regulate tumor hierarchy

PRC2 and MLL1/2 cooperate to guide developmental programs recapitulated in tumors.

Taking advantage of the genetic opportunities offered by a Drosophila brain tumour model, the Maurange team systematically investigated how the inactivation of epigenetic factors, often mutated in paediatric cancers, affects the cellular hierarchy and growth of tumours. Combined with single-cell RNA-seq approaches, they showed that inactivation of two chromatin complexes, known to have an antagonistic function during development (polycomb/PRC2 and trithorax/MLL1/2), can cooperate to induce plasticity in the cellular hierarchy and heterogeneity in the pool of cancer stem cells. This study paves the way to a better understanding of the role of epigenetic factors in cancer progression and resistance to treatments.

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Dernières publications

Show me your rhythm!

We introduce an algorithm, Phasik, for extracting the phases of biological systems by clustering partial temporal networks.

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TWITTER

02/02/2023

How disruption drives change

Interaction between tight junction formation and gastrulation signals regulates mesendoderm differentiation in hiPSCs

01/02/2023

Show me your rhythm!

We introduce an algorithm, Phasik, for extracting the phases of biological systems by clustering partial temporal networks.