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Self-organisation of human muscles in a dish
Human muscle cells self-organise into defined fiber bundles in vitro even without the presence of external cues !
INSTITUTE OF DEVELOPMENTAL BIOLOGY
Human muscle cells self-organise into defined fiber bundles in vitro even without the presence of external cues !
PRC2 and MLL1/2 cooperate to guide developmental programs recapitulated in tumors.
The Bertrand team shows that PRC1 chromatin factors play a role in the robustness of neuronal fate against gene expression noise and environmental perturbations.
EMBO elects 67 new members and associate members. They join the community of more than 1,900 leading life scientists in Europe and beyond.
The Lenne team published in Elife: using gastruloids –3D aggregates of mouse embryonic stem cells- they study at cellular resolution the specification of the endoderm.
Nos résultats apportent un éclairage nouveau sur l’implication du circuit corticostrié dans les TSA.
In this study, the Mann team showed that pancreatic cancer development promotes the sprouting and growth of sympathetic axons.
The Helmbacher team identified the Fat1 Cadherin as a novel regulator of retinal vascular integrity, and investigated the underlying mechanisms.
Our work demonstrates that by activating the NF-kB pathway, cell wall peptidoglycan produced by these same bacteria, counteracts SREBP activation in adipocytes in a cell-autonomous manner.
Our results allow us to propose a simple and efficient model of how life could generate new functions through the use of new actin isoforms.