MARSEILLE INSTITUTE OF DEVELOPMENTAL BIOLOGY

Job opportunitites

Post-doctoral researcher in molecular biology

Project description

A post-doctoral position in molecular biology is open for recruitment within the “Neural Stem Cell Plasticity” team (2 years + 1 year renewable) to study how microRNAs regulate the cellular hierarchy of pediatric tumors.

The successful candidate will work on a pediatric brain tumor model developed in Drosophila (PMID: 27296804 ; PMID: 31566561 ; PMID: 35544555). He/she will use a new technology developed by the team enabling in vivo isolation of microRNAs expressed at different stages of the cell hierarchy. 

Bioinformatic analysis of the microRNAs will enable us to identify modules specifically targeting the regulators of the tumor cell hierarchy. The generation of “multi-sponge” transgenic lines will enable inactivation of the microRNA module targeting the regulators of the cell hierarchy. This study will provide proof of concept that the inactivation of microRNA modules can be used as a therapeutic means of controlling tumor cell hierarchy with a view to eliminating cancer stem cells. 

The post-doc will benefit from the scientific environment of IBDM, a world-renowned institute working on embryonic development and associated diseases. 

Activities

  • Drosophila genetics
  • Purification of microRNAs
  • Cloning
  • Basic bioinformatics analysis
  • Immunolabeling and confocal microscopy analysis
 

Progress will be regularly presented in English at team meetings and scientific conferences. 

Skills

In addition to their own motivation and enthusiasm to participate in the advancement of scientific knowledge, the successful candidate will need to have the following skills or experience: 

Skills required:

  • Molecular biology techniques (RNA extraction, cloning, immunochemistry, immunoprecipitation)
  • Solid knowledge of cell biology, developmental biology and cancer
  • Ability to discuss and write in English
 

Skills appreciated but not mandatory:

  • Drosophila genetics
  • Bioinformatics (sequencing data alignment, enrichments etc) 

Profile required

  • Recent PhD in molecular biology
  • Good communication skills
  • Ability to work as part of a team, good listening and reading skills

Contact

Type of position

TEAMS

OPEN POSITIONS

Pattern formation by self-organized cell movement

The selected candidate will receive training in the following areas: molecular biology, cell biology, Xenopus micro-injection and micro-surgery, fluorescent confocal microscopy, video-microscopy, numerical image analysis.