We are pleased to announce the publication in eLife of a study that describes and deciphers how Drosophila larvae discriminate bacteria in the gut, trapping and killing pathogenic ones while allowing others to reach the posterior part of the gut, where they may possibly reside.
This study builds on a pioneering observation made 10 years ago by Bernard CHARROUX. It is the result of a collaboration with the INRAE team led by Armel GALLET at Nice, Sophia Antipolis, and the shared work of three PhD students, including Martina MONTANARI and Romane MILLEVILLE.
Feel free to visualize:
A larva that wins the fight against a GFP-producing pathogen:
Tleiss et al_Movie 1_ctrl vs Ecc-gfp
A larva that loses the fight against a GFP-producing pathogen:Tleiss et al_Movie 4_TrpA1 vs Ecc-gfp
A larva that lets innocuous GFP-producing bacteria pass through:Tleiss et al_Movie 3-ctrl vs Lp
Tleiss F, Montanari M, Milleville R, Pierre O, Royet J, Osman D, Gallet A, Kurz CL. Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae. Elife. 2024 Nov 22;13:RP98716.
