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Trap then kill: coordination key to fly larvae survival.

Using ROS, larvae coordinate trapping harmful gut bacteria with a valve, then kill them with antimicrobial peptides.
Picture of Delphine Dauga
Delphine Dauga
Biocurator at Bioself
Date de publication

We are pleased to announce the publication in eLife of a study that describes and deciphers how Drosophila larvae discriminate bacteria in the gut, trapping and killing pathogenic ones while allowing others to reach the posterior part of the gut, where they may possibly reside.

This study builds on a pioneering observation made 10 years ago by Bernard Charroux. It is the result of a collaboration with the INRAE team led by Armel Gallet at Nice, Sophia Antipolis, and the shared work of three PhD students, including Martina Montanari and Romane Milleville.

Tleiss F, Montanari M, Milleville R, Pierre O, Royet J, Osman D, Gallet A, Kurz CL. Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae. Elife. 2024 Nov 22;13:RP98716. doi: 10.7554/eLife.98716. PMID: 39576741; PMCID: PMC11584180.

Feel free to visualize:

A larva that wins the fight against a GFP-producing pathogen:

A larva that loses the fight against a GFP-producing pathogen:

A larva that lets innocuous GFP-producing bacteria pass through:

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