Stem cells and brain repair
Our team seeks to understand the repair process in the adult brain and more specifically the myelin regeneration.
Myelin is a sheath that surrounds and insulates the nerve, and improves signal transmission. When myelin is damaged or abnormal, due to genetic abnormalities, trauma or neurodegenerative diseases such as multiple sclerosis, neurological disorders occur resulting in severe disability.
The nervous system is capable, to a certain extent, to regenerate the myelin sheath, but this self-repair process is incomplete and insufficient. This regeneration is possible thanks to the presence in the brain of stem cells and progenitor cells that can replace oligodendrocytes the myelin forming cell. It is therefore important to understand all the mechanisms involved in the process of myelin repair in order to develop new therapeutic strategies.
Our research aims to better understand the biology of adult progenitor and stem cells involved in remyelination. Our goal is to decipher the cellular and molecular mechanisms controlling the mobilization of these cells. We are trying to determine which cells are involved in the repair process. How these cells migrate to the lesion site? What are the factors that control their differentiation into oligodendrocytes in physiological and pathological conditions? We are looking for factors that can influence or control these events when administered to the animal. We use the mouse as a model organism and combine techniques of cell biology, molecular imaging and neurosurgery to answer these questions.
Publications
Our last publications
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Team Pascale Durbec
Endogenous neural stem cells modulate microglia and protect against demyelination
Team Pascale Durbec
Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production
Team Pascale Durbec
Promoting Myelin Repair through In Vivo Neuroblast Reprogramming
B.El Waly
Et Al.
M.Cayre
P.Durbec
Team Pascale Durbec
Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome
Team Pascale Durbec
Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules
Team Pascale Durbec
Region and dynamic specificities of adult neural stem cells and oligodendrocyte precursors in myelin regeneration in the mouse brain
B.Brousse
Et Al.
K.Magalon
P.Durbec
M.Cayre
All
Team Pascale Durbec
Neuroblasts contribute to oligodendrocytes generation upon demyelination in the adult mouse brain
Team Pascale Durbec
Endogenous neural stem cells modulate microglia and protect against demyelination
Team Pascale Durbec
Myelin repair: from animal models to humans.
Team Pascale Durbec
Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulphate production
Team Pascale Durbec
Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production
Team Pascale Durbec
Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy
Team Pascale Durbec
Promoting Myelin Repair through In Vivo Neuroblast Reprogramming
B.El Waly
Et Al.
M.Cayre
P.Durbec
Team Pascale Durbec
Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome
Team Pascale Durbec
Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules
Team Pascale Durbec
Region and dynamic specificities of adult neural stem cells and oligodendrocyte precursors in myelin regeneration in the mouse brain
B.Brousse
Et Al.
K.Magalon
P.Durbec
M.Cayre
Team Pascale Durbec
Oligodendrogenesis in the normal and pathological central nervous system.
E.Waly B
Et Al.
M.M
C.M
D.P.
Team Pascale Durbec
Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero.
Team Pascale Durbec
Netrin 1 contributes to vascular remodeling in the subventricular zone and promotes progenitor emigration after demyelination.
Team Pascale Durbec
Ciliary Neurotrophic Factor Controls Progenitor Migration during Remyelination in the Adult Rodent Brain.
Team Pascale Durbec
Sonic Hedgehog Signaling Is a Positive Oligodendrocyte Regulator during Demyelination.
Team Pascale Durbec
Olesoxime accelerates myelination and promotes repair in models of demyelination.
Team Pascale Durbec
A lateral belt of cortical LGN and NuMA guides mitotic spindle movements and planar division in neuroepithelial cells.
Team Pascale Durbec
Reelin controls progenitor cell migration in the healthy and pathological adult mouse brain.
Team Pascale Durbec
RAE-1 is expressed in the adult subventricular zone and controls cell proliferation of neurospheres.
Team Pascale Durbec
Cell migration in the normal and pathological postnatal mammalian brain
C.M
Et Al.
C.P
G.JE.
Team Pascale Durbec
Intranasal HB-EGF administration favors adult SVZ cell mobilization to demyelinated lesions in mouse corpus callosum.
Team Pascale Durbec
Characterization of heterogeneous glial cell populations involved in dehydration-induced proliferation in the adult rat neurohypophysis.
Team Pascale Durbec
LIFR beta plays a major role in neuronal identity determination and glial differentiation in the mouse facial nucleus.
Team Pascale Durbec
Control of planar divisions by the G-protein regulator LGN maintains progenitors in the chick neuroepithelium.
M.X
Et Al.
J.F
Â.P.
Team Pascale Durbec
Relevance of combinatorial profiles of intermediate filaments and transcription factors for glioma histogenesis.
Team Pascale Durbec
PSA-NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival.
Team Pascale Durbec
Enriched environment promotes adult neural progenitor cell mobilization in mouse demyelination models.
Team Pascale Durbec
In vitro identification and functional characterization of glial precursor cells in human gliomas.
Team Pascale Durbec
Migrating and myelinating potential of subventricular zone neural progenitor cells in white matter tracts of the adult rodent brain.
Team Pascale Durbec
Oligodendrocyte precursor cells generate pituicytes in vivo during neurohypophysis development.
Team Pascale Durbec
A role for the polysialic acid-neural cell adhesion molecule in PDGF-induced chemotaxis of oligodendrocyte precursor cells.
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3 motivated and talented students successfully defended their thesis between February and July 2023.
5 motivated and talented students successfully defended their thesis between September 2022 and January 2023.
10/08/2021
7 IBDM teams have received grants from ANR
7 IBDM teams have received grants from the Agence Nationale pour la Recherche (ANR) in 2021. Congratulations to Vincent Bertrand, Harold Cremer, Pascale Durbec, André Le Bivic, Pierre-François
A study recently published in elife by the Durbec’s team in collaboration with Anna Williams showed that mature OLG cells spared by the degenerative process surrounding demyelinated lesions also contribute to this repair mechanism by producing HS and modulating Shh signaling pathway.
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Magali Macchi
Enseignant chercheur chez Aix-Marseille Université
Xavier Morin
CNRS Researcher
Françoise Padilla
Responsable Equipe Imagerie Photonique
Fabienne Alfonsi
Medical Marketing Director chez Teoxane Laboratories