INSTITUT DE BIOLOGIE DU DEVELOPPEMENT DE MARSEILLE

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Transformation of neuroblasts into oligodendrocytes

Neuroblasts can generate myelinating oligodendrocytes in pathological states.
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In this article, the Durbec team showed that neuroblasts, which give rise to neurons in physiological conditions, generate myelinating oligodendrocytes in pathological states. This fate change occurs directly by forming a transient cell state co-expressing neuronal and oligodendrocyte identity markers. This conversion involves fine-tuning of transcriptional and translational mechanisms and regulation of cell metabolism and migratory behaviour.

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