In this article, the Durbec team showed that neuroblasts, which give rise to neurons in physiological conditions, generate myelinating oligodendrocytes in pathological states. This fate change occurs directly by forming a transient cell state co-expressing neuronal and oligodendrocyte identity markers. This conversion involves fine-tuning of transcriptional and translational mechanisms and regulation of cell metabolism and migratory behaviour.
We Are Recruiting Group Leaders
The Institut de Biologie du Développement de Marseille (IBDM) is inviting applications for group leader positions. We are seeking innovative researchers who aim to address fundamental questions in biology, including the development, function, and dynamics of complex biological systems.
