INSTITUT DE BIOLOGIE DU DEVELOPPEMENT DE MARSEILLE

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Transformation of neuroblasts into oligodendrocytes

Neuroblasts can generate myelinating oligodendrocytes in pathological states.
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In this article, the Durbec team showed that neuroblasts, which give rise to neurons in physiological conditions, generate myelinating oligodendrocytes in pathological states. This fate change occurs directly by forming a transient cell state co-expressing neuronal and oligodendrocyte identity markers. This conversion involves fine-tuning of transcriptional and translational mechanisms and regulation of cell metabolism and migratory behaviour.

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We Are Recruiting Group Leaders

The Institut de Biologie du Développement de Marseille (IBDM) is inviting applications for group leader positions. We are seeking innovative researchers who aim to address fundamental questions in biology, including the development, function, and dynamics of complex biological systems.

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Jules Vanaret

This thesis explores the biophysical and computational modeling of self-organization

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24/03/2025

We Are Recruiting Group Leaders

The Institut de Biologie du Développement de Marseille (IBDM) is inviting applications for group leader positions. We are seeking innovative researchers who aim to address fundamental questions in biology, including the development, function, and dynamics of complex biological systems.