In this article, the Durbec team showed that neuroblasts, which give rise to neurons in physiological conditions, generate myelinating oligodendrocytes in pathological states. This fate change occurs directly by forming a transient cell state co-expressing neuronal and oligodendrocyte identity markers. This conversion involves fine-tuning of transcriptional and translational mechanisms and regulation of cell metabolism and migratory behaviour.
MYC and MET, the ‘Bonnie and Clyde’ in the liver
A new genetic cooperation acting on liver cancer has been uncovered in patients and functionally documented in vivo