The tumor-infiltrated sympathetic nerve fibers act as a brake on cancer progression by preventing recruitment of tumor-promoting macrophages. These findings may have implications for the targeted manipulation of nerves and neural signaling in cancer therapy.
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Guillot J, Dominici C, Lucchesi A, Nguyen HTT, Puget A, Hocine M, Rangel-Sosa MM, Simic M, Nigri J, Guillaumond F, Bigonnet M, Dusetti N, Perrot J, Lopez J, Etzerodt A, Lawrence T, Pudlo P, Hubert F, Scoazec JY, van de Pavert SA, Tomasini R, Chauvet S, Mann F. Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer. Nat Commun. 2022 Apr 13;13(1):1985. doi: 10.1038/s41467-022-29659-w.