INSTITUT DE BIOLOGIE DU DEVELOPPEMENT DE MARSEILLE

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Nervous But Sympathetic !

In this study, the Mann team showed that pancreatic cancer development promotes the sprouting and growth of sympathetic axons.
Date de publication

The tumor-infiltrated sympathetic nerve fibers act as a brake on cancer progression by preventing recruitment of tumor-promoting macrophages. These findings may have implications for the targeted manipulation of nerves and neural signaling in cancer therapy.

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Guillot J, Dominici C, Lucchesi A, Nguyen HTT, Puget A, Hocine M, Rangel-Sosa MM, Simic M, Nigri J, Guillaumond F, Bigonnet M, Dusetti N, Perrot J, Lopez J, Etzerodt A, Lawrence T, Pudlo P, Hubert F, Scoazec JY, van de Pavert SA, Tomasini R, Chauvet S, Mann F. Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer. Nat Commun. 2022 Apr 13;13(1):1985. doi: 10.1038/s41467-022-29659-w.

 

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Dernières publications

Show me your rhythm!

We introduce an algorithm, Phasik, for extracting the phases of biological systems by clustering partial temporal networks.

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TWITTER

02/02/2023

How disruption drives change

Interaction between tight junction formation and gastrulation signals regulates mesendoderm differentiation in hiPSCs

01/02/2023

Show me your rhythm!

We introduce an algorithm, Phasik, for extracting the phases of biological systems by clustering partial temporal networks.