Pourquoi ne pas ANNOtater et ‘MINEr’ vos données ChIP-seq avec AnnoMiner ?

Nous présentons 'AnnoMiner', un nouvel outil convivial basé sur le web pour annoter et intégrer les données épigénétiques et de liaison des facteurs de transcription.
Date de publication

Gene regulation is a highly complex process, involving often several transcriptional regulators, sometimes over long distances on the chromosome and involving 3D chromatin structure. ChIP-seq and related techniques have helped us refine our picture of the gene regulatory process. Tools to analyze such data are often not easily accessible for wet-lab researchers, nor do they consider the complexity of this process. With AnnoMiner, we introduce a novel, user-friendly web-based tool to annotate and integrate epigenetic and transcription factor binding data. AnnoMiner gives full control to the user and you can choose, which peak – gene relationship you want to explore. Furthermore, it allows exploring genes at long distances up- or downstream from a peak. As a big bonus, you can integrate up to five genomic peak datasets with each other, and even adding information from e.g. RNA-seq on differentially expressed genes. You can also use AnnoMiner to find enriched transcription factor or histone mark peaks for a list of genes that are, for instance, co-regulated. You can find AnnoMiner here. This work is part of Fabio Marchiano’s PhD thesis (and was started already some time ago with his co-first author, Arno Meiler). It is also the product of a fruitful collaboration between the Habermann and Schnorrer teams.

Find out more: Meiler A, Marchiano F, Haering M, Weitkunat M, Schnorrer F, Habermann BH. AnnoMiner is a new web-tool to integrate epigenetics, transcription factor occupancy and transcriptomics data to predict transcriptional regulators. Sci Rep. 2021 Jul 29;11(1):15463. doi: 10.1038/s41598-021-94805-1.



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