Event Type: PhD defense

Mechanical forces play a fundamental role in protein function, influencing how proteins fold, unfold (or stretch), and interact in biological systems. Specific sequence motifs and

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, marked by rapid proliferation, diffuse infiltration, and therapeutic resistance. Increasing evidence suggests that neural

Early mammalian development remains poorly understood, mainly due to the inaccessibility of embryos in utero. To overcome this limitation, recent studies have demonstrated that embryonic

Le toucher est l’un des sens le plus sollicité dès la naissance et demeure essentiel tout au long de la vie pour diverses fonctions, y

This thesis explores the biophysical and computational modeling of self-organization in gastruloids, three-dimensional in vitro models of embryonic development. It investigates how cellular decisions emerge

Ventricular arrhythmias, including ventricular fibrillation, account for a significant proportion of sudden cardiac deaths. Although the Purkinje fibers are implicated in the development of these

While morphogenesis involves the coordinated movements and interactions of neighbouring tissues, the precise role of tissue-tissue interactions in guiding morphogenesis remains largely unknow. Here, we

Muscle development involves complex networks of transcriptional regulators that ensure the specification and diversification of different muscle types. The identification of these factors is essential

The global opiate crisis has highlighted how unsatisfactory current pain treatments are. Our team has recently shown that the neuropeptide TAFA4, which is enriched in

In this thesis, I present the development of user-friendly and web-based tools for several types of transcriptomics data. First, I developed a R-shiny app to