This thesis explores the biophysical and computational modeling of self-organization in gastruloids, three-dimensional in vitro models of embryonic development. It investigates how cellular decisions emerge
Ventricular arrhythmias, including ventricular fibrillation, account for a significant proportion of sudden cardiac deaths. Although the Purkinje fibers are implicated in the development of these
While morphogenesis involves the coordinated movements and interactions of neighbouring tissues, the precise role of tissue-tissue interactions in guiding morphogenesis remains largely unknow. Here, we
Muscle development involves complex networks of transcriptional regulators that ensure the specification and diversification of different muscle types. The identification of these factors is essential
The global opiate crisis has highlighted how unsatisfactory current pain treatments are. Our team has recently shown that the neuropeptide TAFA4, which is enriched in
In this thesis, I present the development of user-friendly and web-based tools for several types of transcriptomics data. First, I developed a R-shiny app to
The nervous system of bilaterian animals is largely bilaterally symmetric. However, some left-right asymmetries exist at the anatomical, molecular and functional levels. One particularly interesting
During development, cells shape epithelial tissues into distinct 3D structures with specialized molecular and mechanical regions. The vertebrate heart tube, for instance, extends by adding
During my PhD thesis, I explored the role of cell mechanics in the development and maintenance of the small intestinal epithelium. I focused on two
In the brain, neurons communicate through synapses. In response to various stimuli, synapses undergo diverse forms of plasticity, leading to the remodelling of synapses and
