This thesis explores the biophysical and computational modeling of self-organization in gastruloids, three-dimensional in vitro models of embryonic development. It investigates how cellular decisions emerge
Ventricular arrhythmias, including ventricular fibrillation, account for a significant proportion of sudden cardiac deaths. Although the Purkinje fibers are implicated in the development of these
The cerebral cortex controls our higher cognitive capacities and helps define us as humans. Cortical development is orchestrated by neural progenitors which give rise to