Team members

Signalling networks for stemness and tumorigenesis

Our team studies resilience versus vulnerability of cells to signalling fluctuations to understand how cancer starts, evolves, and responds to treatments.

Our team studies resilience versus vulnerability of cells to signalling fluctuations to understand how cancer starts, evolves, and responds to treatments. A key tool in our studies is a unique mouse genetic setting in which slightly increased wild-type receptor tyrosine kinase levels trigger the tumorigenic program in vulnerable tissues: liver and mammary gland. This “inside-out” genetic setting is a predisposing cancer model open to a variety of spontaneous alterations, thoroughly recapitulating disease features occurring in human patients. By combining complementary tools within interdisciplinary approaches, we identify new mechanisms at the root of tissue homeostasis destabilisation, tumour initiation, progression, as well as vulnerabilities to exploit for targeted therapies. Furthermore, we study how qualitative and quantitative signalling changes lead to diversified cell behaviours using stem cell cultures, organoids, and tumoroids, to document how perception of environmental signals and modulation of epithelial integrity impact cell behaviour, cell-cell interaction, and the acquisition of diversified cell identities.

Drosophila suzukii assesses the quality of a ripe cherry before deciding where to lay an egg

Publications

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of the team

Alumni

They contributed to our research
Yannan Fan
Postdoctoral Researcher INSERM, France
Francesca Zaccagnino
Postdoctoral Researcher at Aix-Marseille Univ, France
Serena Corti
Stem Cell Scientist at University of Tübingen, Germany
Sehrish Khan Bazai
postdoc at the Institute of Genetics and Molecular and Cellular Biology (IGBMC), France
Diane Rattier
Scientific Researcher at Poietis-Pan3D, France
Ahmed Abdouni
Senior Scientist, Veracyte, Inc., France
Fahmida Ahmad
Lecturer at SBK Women’s at the University of Quetta, Pakistan
Rémi Bonjean
Ingénieur d’études at Aix-Marseille Univ, France

Funding bodies

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